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Old 04-24-2012, 11:26 AM   #21
Bill Ennis
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Hi;
I haven't been here in a while and I know this thread is a little old.
Could anyone comment on the reported increase risk of pancreatic and esophageal cancer in patients with high(> 40ng/ml) levels of 25-hydroxyvitamin D?
This was mentioned in a "Perspective" piece in the New England Journal of Medicine(April 14, 2011, pg. 1387) and referenced a study by Helzlsouer entitled, " Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers" , Am J of Epidemiology 2010; 172:4-9.
I haven't tracked the paper down yet. Just wondering if anyone was familiar with it.
Thanks.
Bill
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Old 04-25-2012, 05:59 AM   #22
Darryl Shaw
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Quote:
Originally Posted by Bill Ennis View Post
Hi;
I haven't been here in a while and I know this thread is a little old.
Could anyone comment on the reported increase risk of pancreatic and esophageal cancer in patients with high(> 40ng/ml) levels of 25-hydroxyvitamin D?
This was mentioned in a "Perspective" piece in the New England Journal of Medicine(April 14, 2011, pg. 1387) and referenced a study by Helzlsouer entitled, " Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers" , Am J of Epidemiology 2010; 172:4-9.
I haven't tracked the paper down yet. Just wondering if anyone was familiar with it.
Thanks.
Bill
I don't have time to look into this at the moment but a quick search of the 2011 IOM report Dietary Reference Intakes for Calcium and Vitamin D found a number of references to pancreatic cancer but none for esophageal cancer. I've only had time to skim though a couple of pages so there may be more to it than this, but it appears as though an increased risk of pancreatic cancer with higher serum 25(OH)D levels was found in just two studies which, again, I don't have time to read.

Hope this helps.

Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.

http://www.nap.edu/openbook.php?book...apter=725-1012

http://www.nap.edu/openbook.php?reco...13050&page=808

A Prospective Nested Case-Control Study of Vitamin D Status and Pancreatic Cancer Risk in Male Smokers.

Office of Dietary Supplements Fact Sheet: Vitamin D.

Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer.

Edit: I've had time to read those studies now and it appears as though there may be an increased risk of pancreatic cancer with very high levels of serum 25(OH)D so if you're concerned you may want to avoid supplements and get your vit. D the old fashioned way - sunlight. As for esophageal cancer, there appears to be an increased risk with higher 25(OH)D levels in Asians, which may in part be due to the prevalence of H. pylori infections in Asia, high salt intake, and a high intake of pickled and fermented foods. There was no increased risk seen in caucasians though so, on balance, I don't think this is something you need to worry about.

I'd be interested to hear Steven Low's thoughts on this though as he's probably more up to date with the research on vit. D than I am.
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Old 10-03-2012, 05:35 AM   #23
Darryl Shaw
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Quote:
Effect of Vitamin D3 Supplementation on Upper Respiratory Tract Infections in Healthy Adults: The VIDARIS Randomized Controlled Trial.

ABSTRACT


Context: Observational studies have reported an inverse association between serum 25-hydroxyvitamin D (25-OHD) levels and incidence of upper respiratory tract infections (URTIs). However, results of clinical trials of vitamin D supplementation have been inconclusive.

Objective: To determine the effect of vitamin D supplementation on incidence and severity of URTIs in healthy adults.

Design, Setting, and Participants: Randomized, double-blind, placebo-controlled trial conducted among 322 healthy adults between February 2010 and November 2011 in Christchurch, New Zealand.

Intervention: Participants were randomly assigned to receive an initial dose of 200 000 IU oral vitamin D3, then 200 000 IU 1 month later, then 100 000 IU monthly (n = 161), or placebo administered in an identical dosing regimen (n = 161), for a total of 18 months.

Main Outcome Measures: The primary end point was number of URTI episodes. Secondary end points were duration of URTI episodes, severity of URTI episodes, and number of days of missed work due to URTI episodes.

Results: The mean baseline 25-OHD level of participants was 29 (SD, 9) ng/mL. Vitamin D supplementation resulted in an increase in serum 25-OHD levels that was maintained at greater than 48 ng/mL throughout the study. There were 593 URTI episodes in the vitamin D group and 611 in the placebo group, with no statistically significant differences in the number of URTIs per participant (mean, 3.7 per person in the vitamin D group and 3.8 per person in the placebo group; risk ratio, 0.97; 95% CI, 0.85-1.11), number of days of missed work as a result of URTIs (mean, 0.76 days in each group; risk ratio, 1.03; 95% CI, 0.81-1.30), duration of symptoms per episode (mean, 12 days in each group; risk ratio, 0.96; 95% CI, 0.73-1.25), or severity of URTI episodes. These findings remained unchanged when the analysis was repeated by season and by baseline 25-OHD levels.

Conclusion: In this trial, monthly administration of 100 000 IU of vitamin D did not reduce the incidence or severity of URTIs in healthy adults.
http://jama.jamanetwork.com/article....icleid=1367547
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